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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can lower panobinostat levels by ~70% and cause cure failure.pentobarbital will lower the level or impact of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknow